E6530

エトミデート

>98% (HPLC), GABAA potentiator, powder

• 別名: R16659, アミデート
• 実験式（ヒル表記法）: C₁₄H₁₆N₂O₂
• CAS番号: 33125-97-2
• 分子量: 244.29
• NACRES: NA.77
• PubChem Substance ID: 24894630
• UNSPSC Code: 12352200
• EC Number: 251-385-9
• MDL number: MFCD00869295
• Assay: >98% (HPLC)
• Form: powder

特性

• 製品名: エトミデート, >98% (HPLC), powder
• Quality Segment: 100
• assay: >98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL
• originator: Johnson & Johnson
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)c1cncn1[C@H](C)c2ccccc2
• InChI: 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
• InChI key: NPUKDXXFDDZOKR-LLVKDONJSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879) ;

詳細

General description

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test. Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes. It inhibits adrenal steroidogenesis.

Biochem/physiol Actions

エトミデ-トは全身麻酔薬であり、GABAA伝達を増強します。ストレプトゾトシン (STZ) 誘発性高血糖に対するエトミデ-トの神経保護作用について、ラットの脳、脊髄を用いて検討されました。エトミデ-ト投与により糖尿病性酸化的損傷に対する神経組織保護の効果が示されました。

Etomidate is a general anesthetic; potentiates GABA_A transmission

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07,GHS09
• 注意喚起語: Warning
• ハザードコード: H302,H410
• 注意事項: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable
• PPE（個人用保護具）: dust mask type N95 (US), Eyeshields, Gloves