E0159

エホニジピン 塩酸塩 モノエタノラート

≥98% (HPLC)

• 実験式（ヒル表記法）: C₃₄H₃₈N₃O₇P · HCl · C₂H₅OH
• CAS番号: 111011-76-8
• 分子量: 714.18
• NACRES: NA.25
• PubChem Substance ID: 329798945
• UNSPSC Code: 12352200
• MDL number: MFCD00875717
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: pale yellow
• solubility: DMSO: >5 mg/mL, H₂O: insoluble
• originator: Shionogi
• storage temp.: 2-8°C
• SMILES string: Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5
• InChI: 1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
• InChI key: IKBJGZQVVVXCEQ-UHFFFAOYSA-N

詳細

Biochem/physiol Actions

エホニジピン塩酸塩は、ある種のL型およびT型カルシウムチャネルをブロックする活性を有するラセミ化合物です。

Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)