D3676

10-Deacetylbaccatin III from Taxus baccata

≥95% (HPLC)

• 実験式（ヒル表記法）: C₂₉H₃₆O₁₀
• CAS番号: 32981-86-5
• 分子量: 544.59
• MDL番号: MFCD00132913
• UNSPSCコード: 51102829
• PubChem Substance ID: 24893778
• NACRES: NA.85

特性

• 由来生物: Taxus baccata
• アッセイ: ≥95% (HPLC)
• 形状: solid
• 分子量: 544.59 g/mol
• 色: white
• 溶解性: methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)
• 抗生物質活性スペクトル: neoplastics
• 作用機序: DNA synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: [H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@@H](O)C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C
• InChI: 1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1
• InChI Key: YWLXLRUDGLRYDR-ZHPRIASZSA-N

詳細

アプリケーション

10-Deacetylbaccatin III is used as a chemical intermediate in the preparation of the anti-cancer drug paclitaxel (Taxol). It is used to study the taxol biosynthetic pathway.

生物化学的／生理学的作用

10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H315,H319,H335,H340,H350,H373
• 注意書き: P202 - P260 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)