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由来生物
goat
結合体
unconjugated
抗体製品の状態
whole antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
含みます
15 mM sodium azide
化学種の反応性
human
テクニック
indirect immunofluorescence: 1:20 using human foreskin fibroblasts
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CLTC(1213)
詳細
Clathrin consists of three heavy chains, along with three light chains. The weight of heavy chains varies depending on the source of clathrin. It forms a three-legged structure termed triskelion with three clathrin heavy chains (molecular weight 180,000 daltons per chain) and three non-covalently bound light chains having molecular weights of 30,000-40,000 daltons per chain. Although the term clathrin was originally used to designate the heavy chain component of triskelions, clathrin is now used to refer to the entire triskelion protein molecule.
Clathrin consists of three heavy chains, along with three light chains. The weight of heavy chains varies depending on the source of clathrin. It forms a three-legged structure, termed triskelion with three clathrin heavy chains (molecular weight 180,000 daltons per chain) and three non-covalently bound light chains having molecular weights of 30,000-40,000 daltons per chain. Although the term clathrin was originally used to designate the heavy chain component of triskelions, clathrin is now used to refer to the entire triskelion protein molecule.
特異性
この製品は、イムノブロッティングでクラスリンH鎖のバンドを特異的に標識します。
免疫原
ウシ脳被覆小胞由来クラスリン
アプリケーション
Anti-Clathrin antibody was used:
- for incubating trophozites (2.105) in a study to determine the role of clathrin in endocytic process of fluid-phase pathway.
- in indirect immunofluorescence staining.
- for immunocytohistochemistry study of human platelets to study the colocalization of adhesive proteins with clathrin in human blood platelets.
生物化学的／生理学的作用
Clathrin is the main constituent of the polygonal network that forms the layer of coated vesicles and coated pits. It is widely assumed that coated vesicles mediate the selective transfer of molecules and membrane components between specific membranous organelles within cells. It is a type of protein which plays an important function within the cell, including various types of intracellular transport processes.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C8034-.2ML:
C8034-BULK:
C8034-VAR:
C8034-1ML:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
M H Klinger et al.
Cell and tissue research, 279(3), 453-457 (1995-03-01)
Coated membranes and vesicles play an important role in receptor-mediated endocytosis and intracellular trafficking in various cell types, and are also present in blood platelets. Platelets take up certain proteins from the blood plasma, such as von Willebrand factor and
S A Morris et al.
The Journal of biological chemistry, 265(6), 3354-3357 (1990-02-25)
Protein kinases which co-purify with clathrin-coated vesicles are known to phosphorylate in vitro the 50-kDa subunit of the HA-II adaptor complex and upon inclusion of polylysine the beta-light chain of clathrin and polypeptides above 100 kDa. Here we relate the
Molecular structure, function, and dynamics of clathrin-mediated membrane traffic
Kirchhausen T, et al.
Cold Spring Harbor Perspectives in Biology, 6(5), a016725-a016725 (2014)
Fernando López-Soto et al.
International journal for parasitology, 39(4), 417-426 (2008-10-14)
Entamoeba histolytica is a parasitic protozoan that produces dysentery and often reaches the liver, leading to abscess formation. Ferritin is an iron-storage protein that is mainly found in liver and spleen in mammals. The liver contains a plentiful source of
M Majeed et al.
Infection and immunity, 59(12), 4465-4472 (1991-12-01)
Immunofluorescence was used to examine the distribution of Chlamydia trachomatis serovars L2 and E, F-actin, and clathrin in infected McCoy and HeLa cells. After incubation at 4 degrees C, C. trachomatis serovar L2 was randomly distributed on the McCoy cell
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