C1480

Z-Phe-Ala fluoromethyl ketone

≥90% (TLC), powder

• 別名: Z-FA-FMK
• 化学式: C₂₁H₂₃N₂O₄F
• 分子量: 386.42
• MDL番号: MFCD00883668
• UNSPSCコード: 12352209
• PubChem Substance ID: 329774889
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥90% (TLC)
• 形状: powder
• 色: white to off-white
• 溶解性: DMSO or DMF: 20 mM
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1
• InChI Key: ASXVEBPEZMSPHB-YJBOKZPZSA-N

詳細

アプリケーション

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:

• cathepsin inhibitor to study its effects on dendritic cells
• papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
• cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages

生物化学的／生理学的作用

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)