B7563

BRD7389

≥98% (HPLC)

• 別名: 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
• 実験式（ヒル表記法）: C₂₄H₁₈N₂O₂
• CAS番号: 376382-11-5
• 分子量: 366.41
• MDL番号: MFCD02924820
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: orange
• 溶解性: DMSO: >20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: [nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4
• InChI: 1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
• InChI Key: XASCINRGTHLHGM-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

BRD7389 is an inhibitor of the RSK kinase family.

BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.

特徴および利点

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable