A8106

アルタンセリン 塩酸塩 水和物

≥98% (HPLC), solid

• 別名: 3-[2-[4-(4-フルオロベンゾイル)-1-ピペリジニル]エチル]-2,3-ジヒドロ-2-チオキソ-4(1H)-キナゾリノン 塩酸塩 水和物
• 実験式（ヒル表記法）: C₂₂H₂₂FN₃O₂S · HCl · xH₂O
• CAS番号: 76330-71-7
• 分子量: 447.95 (anhydrous basis)
• MDL番号: MFCD11045280
• UNSPSCコード: 12352200
• PubChem Substance ID: 329770947
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: DMSO: >5 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: O.Cl.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=S)Nc4ccccc4C3=O
• InChI: 1S/C22H22FN3O2S.ClH.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;;/h1-8,16H,9-14H2,(H,24,29);1H;1H2
• InChI Key: MFGBKMPKRJCLPK-UHFFFAOYSA-N

詳細

アプリケーション

Altanserin hydrochloride hydrate has been used in the pretreatment of rat brain samples and as a non-radioactive control in the calibration curve preparation for quantifying ^[18F]altanserin in high-performance liquid chromatography.

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist and has been used in a study to assess serotonin release capacity in the human brain.

生物化学的／生理学的作用

The radioligand of altanserin, ^[18F]altanserin is useful as a positron emission tomography (PET)-radioligand for the visualization and quantification of serotonin_2A (5-HT_2A) receptors.

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves