A6486

AS-136A

≥98% (HPLC)

• 別名: 1-メチル-N-[4-(1-ピペリジニルスルホニル)フェニル]-3-(トリフルオロメチル)-1H-ピラゾール-5-カルボキサミド, CID 16122506, SID 24769845;
• 実験式（ヒル表記法）: C₁₇H₁₉F₃N₄O₃S
• CAS番号: 949898-66-2
• 分子量: 416.42
• MDL番号: MFCD16875415
• UNSPSCコード: 12352200
• PubChem Substance ID: 329770896
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to off-white
• 溶解性: DMSO: >10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cn1nc(cc1C(=O)Nc2ccc(cc2)S(=O)(=O)N3CCCCC3)C(F)(F)F
• InChI: 1S/C17H19F3N4O3S/c1-23-14(11-15(22-23)17(18,19)20)16(25)21-12-5-7-13(8-6-12)28(26,27)24-9-3-2-4-10-24/h5-8,11H,2-4,9-10H2,1H3,(H,21,25)
• InChI Key: OJDLQNVQEAZKSL-UHFFFAOYSA-N

詳細

アプリケーション

AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays.

生物化学的／生理学的作用

AS-136A is a potent measles virus RdRp inhibitor. Measles virus (MV) is a member of the paramyxovirus family. Ribavirin (R9644) is the only drug available for treatment of paramyxoviruses, and it has limited efficacy against MV. A series of small molecules has been developed to inhibit viral RNA-dependent RNA polymerase (RdRp), a protein vital to infection leading to the development of AS-136A, a very potent RdRp inhibitor. AS-136A has high stability and continues to decrease virus titer after 24 hours in physiologic conditions. AS-136A is now used as a positive control in experiments assaying MV inhibition. This compound is a product of the NIH Probes effort, also known as SID 24769845.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319
• 注意書き: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable