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A5486

アゾキシメタン

13.4 M, ≥98%

別名:

AOM

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あなたへ/カタログ番号在庫状況単価
25 mg
カートの在庫状況を確認する
¥89,000
100 mg
カートの在庫状況を確認する
¥301,000

この商品について

化学式:
CH3N=N(→O)CH3
CAS番号:
分子量:
74.08
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352124
MDL number:
Assay:
≥98%
Form:
liquid
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)

¥89,000


カートの在庫状況を確認する

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Quality Segment

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

General description

アゾキシメタン(AOM)は、がん(特に結腸がん)の発生、進行、および予防を研究するために使用される有力な実験用化学物質です。AOMは、腫瘍形成をトリガする発がん性物質、およびDNAの特定の改変を引き起こす遺伝子変異試薬の両方として機能します。

Application

遺伝子変異試薬であるアゾキシメタン(AOM)は、癌の進展や化学予防のメカニズム研究に使用される実験動物において、癌モデルを作成するために、デキストラン硫酸ナトリウム(DSS)と共に使用されることがあります。

Biochem/physiol Actions

DNA内でO6-メチルグアニン付加体を誘導し、G→Aの変換を生じさせる発がん物質。実験動物の結腸に腫瘍発生を誘導し、癌の進行と化学予防のメカニズムを研究するのに使用されます。

Features and Benefits

汎用性が高く、さまざまな実験用途と研究用途に適用可能。

Other Notes

メルクの生化学製品に関する追加情報については、このフォームに必要事項を入力してください。
実験動物の早期死亡を回避するための実験デザインにとってアゾキシメタンの正確な投与量を設定するために極めて重要です。

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当該品目
292505118502344906
assay

≥98%

assay

≥95% (NMR)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

liquid

form

liquid

form

liquid

form

liquid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

color

colorless

color

yellow

color

-

color

-


signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

保管分類

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

第4類:引火性液体 + 第二石油類 + 危険等級III + 非水溶性液体

fsl

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

A5486-25MG:4.548173961675E12 + A5486-100MG:4.548173961668E12

jan



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質問

1–10/11 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      役に立ちましたか?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 回答
    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      役に立ちましたか?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 回答
    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

      役に立ちましたか?

  5. Is Axozymethane volatile?

    1 回答
    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

      役に立ちましたか?

  6. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    1 回答
    1. Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

      役に立ちましたか?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 回答
    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

      役に立ちましたか?

  8. What is the Department of Transportation shipping information for this product?

    1 回答
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      役に立ちましたか?

  9. How does the storage temperature relate to shipping conditions?

    1 回答
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      役に立ちましたか?

  10. How does azoxymethane act to cause cancers?

    1 回答
    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      役に立ちましたか?

1–10/11 質問  

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