This IC50 for this compound has not been determined. A brief search of the literature shows a fairly broad range in various organisms and/or tissue types. A more thorough literature search would be advised.
A3085
5-(N-エチル-N-イソプロピル)アミロライド
≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor
別名:
EIPA
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
25 mg | 在庫from市川市大町368 | ￥58,400 |
100 mg | 在庫from市川市大町368 | ￥125,000 |
この商品について
実験式（ヒル表記法）:
C11H18ClN7O
CAS番号:
分子量:
299.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder
製品名
5-(N-エチル-N-イソプロピル)アミロライド,
biological source
synthetic
Quality Segment
assay
≥98% (TLC)
form
powder
mp
202-205 °C (lit.)
solubility
methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
storage temp.
2-8°C
SMILES string
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
QDERNBXNXJCIQK-UHFFFAOYSA-N
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)
Application
5-（N-エチル-N-イソプロピル）アミロライドは、以下の用途で添加されています：
- ヒト肺微小血管内皮細胞を培養するための内皮細胞増殖培地
- ショウジョウバエ幼虫のライブイメージング用のPluronic F-127ストック溶液
- in vivoでの空腸ループ灌流に対するNa+/H+阻害の影響を調べるため、実験的灌流液の塩化コリン溶液
Biochem/physiol Actions
Na+/H+対向輸送の選択的ブロッカ-
1 of 1
当該品目 | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% | assay ≥98% (TLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow | solubility methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow | solubility DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow | solubility chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow |
| Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) | Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) | Gene Information human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846) | Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363) |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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¿Cuál es el IC50 de esta sustancia?
1 回答-
役に立ちましたか？
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What is the Department of Transportation shipping information for this product?
1 回答-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
役に立ちましたか？
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How can I store a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 回答-
We do not have solution stability information for 5-(N-Ethyl-N-isopropyl)amiloride. The product is sensitive to light, particularly in solution. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
役に立ちましたか？
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What can I use to make a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 回答-
We test solubility of 5-(N-Ethyl-N-isopropyl)amiloride in methanol (10 mg/mL), yielding a clear yellow solution. It is also soluble in DMSO, and in dilute aqueous acid. It is insoluble in water.
役に立ちましたか？
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What concentration of Product A3085, 5-(N-Ethyl-N-isopropyl)amiloride, should I use in my experiment?
1 回答-
We have the following references for the use of 5-(N-Ethyl-N-isopropyl)amiloride. A review article mentions the use of EIPA at 1 micromolar to probe Na+ channels in rat alveolar epithelial cells; see: Matalon, S., et al., Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am. J. Physiol., 271, L1-L22 (1996). A study of the effects of EIPA on infarction in isolated rabbit hearts and cardiomyocytes has been reported; see: Sato, H., et al., The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart. Basic Res. Cardiol., 92, 339-350 (1997).
役に立ちましたか？
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