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由来生物
mouse
品質水準
100
500
結合体
unconjugated
抗体製品の状態
diluted ascites fluid
抗体製品タイプ
primary antibodies
クローン
R4A, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
フォーム
buffered aqueous solution
交差性
human
包装
vial of 0.1 mL concentrate (377M-14)
vial of 0.5 mL concentrate (377M-15)
bottle of 1.0 mL predilute (377M-17)
vial of 1.0 mL concentrate (377M-16)
bottle of 7.0 mL predilute (377M-18)
メーカー／製品名
Cell Marque®
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
アイソタイプ
IgG1
コントロール
bladder, leiomyoma
輸送温度
wet ice
保管温度
2-8°C
視覚化
cytoplasmic, nuclear
遺伝子情報
human ... SMTN(6525)
詳細
Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin. To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors. Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
Smoothelin Positive Control Slides, Product No. 377S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: [email protected]
法的情報
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
Lot/Batch Number
R E Jimenez et al.
Advances in anatomic pathology, 7(1), 13-25 (2000-01-20)
One of the challenging areas in genitourinary pathology is the recognition of early invasion in urothelial neoplasia. Not uncommon, the patterns of invasion into lamina propria are subtle because a desmoplastic response is absent. Tangential sectioning due to inability to
C Maake et al.
The Journal of urology, 175(3 Pt 1), 1152-1157 (2006-02-14)
We established the expression pattern of smoothelin, a marker protein for contractile smooth muscle cells, in the human detrusor and investigated its possible impact on bladder overactivity. Detrusor samples of 13 overactive bladders (sensory urge and detrusor instability) were obtained
Gladell P Paner et al.
The American journal of surgical pathology, 34(6), 792-799 (2010-04-28)
Accurate recognition of muscularis propria invasion by urothelial carcinoma is vital as it serves as a crossroad between conservative and aggressive clinical management. Recently, there has been attention to the hyperplastic pattern of muscularis mucosae which may mimic the muscularis
Gladell P Paner et al.
The American journal of surgical pathology, 33(1), 91-98 (2008-10-22)
Accurate recognition of urinary bladder muscularis propria (MP) invasion by urothelial carcinoma is crucial as it is the critical crossroad between conservative and aggressive management for the patient. It is now widely known that an inconsistent layer of muscularis mucosae
Dominique P Coco et al.
The American journal of surgical pathology, 33(12), 1795-1801 (2009-12-02)
Smoothelin is a smooth muscle-specific cytoskeletal protein exclusively found in differentiated smooth muscle cells. This contrasts with other smooth muscle proteins (eg, h-caldesmon, alpha-smooth muscle actin, desmin, smooth muscle myosin), which are expressed in proliferative (early) stages of smooth muscle
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