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Merck

PHR1302

Supelco

Pramoxine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

Pramoxine hydrochloride, 4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride

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About This Item

実験式(ヒル表記法):
C17H27NO3 · HCl
CAS番号:
分子量:
329.86
EC Number:
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

グレード

certified reference material
pharmaceutical secondary standard

品質水準

認証

traceable to USP 1554002

APIファミリー

pramoxine

CofA

current certificate can be downloaded

テクニック

HPLC: suitable
gas chromatography (GC): suitable

アプリケーション

pharmaceutical (small molecule)

フォーマット

neat

保管温度

2-30°C

SMILES記法

Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChI Key

SYCBXBCPLUFJID-UHFFFAOYSA-N

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詳細

Pramoxine hydrochloride is a hydrochloride salt of pramoxine, widely used for its local anesthetic and antipruritic properties. Its ability to relieve itching arises from its stabilizing effect on the neuronal membranes of the nerve terminals. It is widely used as a pain medicine for various conditions such as skin irritations, rashes, hemorrhoids, and minor wound care.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Pramoxine hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的/生理学的作用

Topical anesthetic for skin or mucous membranes

アナリシスノート

このような2次標準は、USP、EP(PhEur)、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA1519 in the slot below. This is an example certificate only and may not be the lot that you receive.

関連製品

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

ターゲットの組織

Respiratory system

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

PHR1302-1G:
PHR1302-1G-PW:


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試験成績書(COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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文書ライブラリにアクセスする

Simultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC
Tavlarakis P,et al
Analytical Methods : Advancing Methods and Applications, 2(6), 722-727 (2010)
Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study
Kircik LH
The Journal of Clinical and Aesthetic Dermatology, 4(2), 48-48 (2011)
Comparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Ibrahim F, et al.
Journal of food and drug analysis, 26(3), 1160-1170 (2018)
Gary Grove et al.
Cutis, 73(2), 135-139 (2004-03-19)
An open-label, single-center, observer-blinded, controlled trial was conducted during the winter months to evaluate the moisturizing and antipruritic effects of a unique formulation of lactic acid 12% neutralized with ammonium hydroxide and pramoxine hydrochloride (HCl) 1% in 24 women with

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