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Merck

PHR1279

Supelco

(+)-L-アスコルビン酸ナトリウム

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

L(+)-アスコルビン酸 ナトリウム塩, ビタミンC ナトリウム塩

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About This Item

実験式(ヒル表記法):
C6H7NaO6
CAS番号:
分子量:
198.11
Beilstein:
3767246
EC Number:
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

グレード

certified reference material
pharmaceutical secondary standard

品質水準

認証

traceable to Ph. Eur. Y0000039
traceable to USP 1613509

APIファミリー

sodium ascorbate

CofA

current certificate can be downloaded

テクニック

HPLC: suitable
gas chromatography (GC): suitable

mp

220 °C (dec.) (lit.)

アプリケーション

pharmaceutical (small molecule)

フォーマット

neat

保管温度

2-30°C

SMILES記法

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI Key

PPASLZSBLFJQEF-RXSVEWSESA-M

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詳細

Sodium ascorbate, also known as E301, is a sodium salt of ascorbic acid. It is generally used as an antioxidant in pharmaceutical formulations and food products.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards and pharmacopeia primary standards.

アプリケーション

Sodium ascorbate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by titrimetry and liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

アナリシスノート

このような2次標準は、USP、EP(PhEur)、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC1682 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

保管分類コード

11 - Combustible Solids

WGK

WGK 1


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

PHR1279-1G-PW:
PHR1279-1G:


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試験成績書(COA)

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Sodium Ascorbate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 35(6), 4018-4018 (2018)
Sodium Ascorbate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6997-6998 (2019)
Sodium Ascorbate
Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, 625-627 (2009)
Aleksander Hinek et al.
Journal of dermatological science, 75(3), 173-182 (2014-07-13)
Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis. Present studies explored whether and how the L-ascorbic acid derivative (+) sodium L-ascorbate (SA) would affect production of collagen and elastic
Martin Sillesen et al.
The journal of trauma and acute care surgery, 76(1), 12-19 (2013-12-26)
Traumatic brain injury (TBI) and hemorrhagic shock (HS) can be associated with coagulopathy and inflammation, but the mechanisms are poorly understood. We hypothesized that a combination of TBI and HS would disturb coagulation, damage the endothelium, and activate inflammatory and

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