BP253

(±)-ミコナゾール 硝酸塩

British Pharmacopoeia (BP) Reference Standard

• 別名: 1-(2,4-ジクロロ-β-[(2,4-ジクロロベンジル)オキシ]フェネチル)イミダゾール
• 実験式（ヒル表記法）: C₁₈H₁₄Cl₄N₂O · HNO₃
• CAS番号: 22832-87-7
• 分子量: 479.14
• EC Number: 245-256-6
• MDL番号: MFCD00058161
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: pharmaceutical primary standard
• APIファミリー: miconazole
• 形状: solid
• シェルフライフ: limited shelf life, expiry date on the label
• メーカー／製品名: BP
• アプリケーション: pharmaceutical; pharmaceutical small molecule
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• InChI Key: MCCACAIVAXEFAL-UHFFFAOYSA-N

詳細

詳細

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

アプリケーション

Miconazole nitrate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Miconazole and Hydrocortisone Acetate Cream

Miconazole and Hydrocortisone Cream

Miconazole and Hydrocortisone Ointment

Miconazole Eye Drops

Miconazole Oromucosal Gel

Miconazole Cream

生物化学的／生理学的作用

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

その他情報

Sales restrictions may apply.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H317
• 注意書き: P280 - P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable