1443500

(±)-ミコナゾール 硝酸塩

United States Pharmacopeia (USP) Reference Standard

• 別名: 1-(2,4-ジクロロ-β-[(2,4-ジクロロベンジル)オキシ]フェネチル)イミダゾール
• 実験式（ヒル表記法）: C₁₈H₁₄Cl₄N₂O · HNO₃
• CAS番号: 22832-87-7
• 分子量: 479.14
• NACRES: NA.24
• PubChem Substance ID: 329750464
• UNSPSC Code: 41116107
• MDL number: MFCD00058161

特性

• grade: pharmaceutical primary standard
• agency: USP
• API family: miconazole
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• InChI key: MCCACAIVAXEFAL-UHFFFAOYSA-N

詳細

General description

この製品は薬局方標準品です。発行元の薬局方により製造・供給されています。MSDSを含む製品情報などの詳しい情報は、発行元の薬局方のウェブサイトよりご確認ください。

Application

Miconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Miconazole Nitrate Cream
• Miconazole Nitrate Topical Powder
• Miconazole Nitrate Vaginal Suppositories

Biochem/physiol Actions

アゾール系抗真菌薬です。作用の様態:エルゴステロール生合成に重要な、シトクロムP450依存性14α-デメチラーゼを阻害します。蓄積した14α-メチル化ステロールは、感受性を有する真菌の膜構造を変化させ、細胞膜透過性を変化させます。細胞内の過酸化物蓄積をもたらす、ペルオキシダーゼも阻害します。

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

安全性情報

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• 保管分類: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352