Astrocytes perform several functions that are essential for normal neuronal activity. They play a critical role in neuronal survival during ischemia and other degenerative injuries and also modulate neuronal recovery by influencing neurite outgrowth. In this study, we investigated the
Methods in molecular biology (Clifton, N.J.), 1996, 217-257 (2019-05-28)
Metabolomics has been successfully applied to study neurological and neurodegenerative disorders including Parkinson's disease for (1) the identification of potential biomarkers of onset and disease progression; (2) the identification of novel mechanisms of disease progression; and (3) the assessment of
Establishment and characterization of immortalized clonal cell lines from fetal rat mesencephalic tissue.
Prasad, K N, et al.
In Vitro Cellular & Developmental Biology. Animal, 30A, 596-603 (1994)
The Journal of biological chemistry, 294(25), 9973-9984 (2019-05-17)
A pathological feature of Parkinson's disease (PD) is Lewy bodies (LBs) composed of α-synuclein (α-syn) amyloid fibrils. α-Syn is a 140 amino acids-long protein, but truncated α-syn is enriched in LBs. The proteolytic processes that generate these truncations are not
PKC? mediates paraquat-induced Nox1 expression in dopaminergic neurons.
Cristov?o, Ana Clara, et al.
Biochemical and biophysical research communications, 437, 380-385 (2013)