フローサイトメトリー:独立した研究所において、200人の健康被験者に由来する末梢血CD3+細胞において、HLA-Cが検出されました(Apps, R., et al. (2013)。Science.340(6128):84-91)。 フローサイトメトリー:独立した研究所において、ヒトPBMCが検出されました(Corrah, T. W., et al. (2011)。J Virol.85(7):3367-3374)。
免疫沈降:独立した研究所において、各種ヒト細胞株でHLA-Cを免疫沈降させました(Braud, V. M., et al. (1998)。Curr Biol. 8(1):1-10)。
Helicobacter pylori (H. pylori) seems to play causative roles in gastric cancers. H. pylori has also been detected in established gastric cancers. How the presence of H. pylori modulates immune response to the cancer is unclear. The cytotoxicity of natural
Functional studies of HIV-1 proteins are normally conducted using lab adapted strains of HIV-1. The extent of those functions in clinical strains is sometimes unknown. In this study, we amplified and sequenced HIV-1 Vpu from 10 Iranian patients infected with
Functional studies of HIV-1 proteins are normally conducted using lab adapted strains of HIV-1. The extent of those functions in clinical strains is sometimes unknown. In this study, we amplified and sequenced HIV-1 Vpu from 10 Iranian patients infected with
HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group
The HIV-1-encoded accessory protein Vpu exerts several immunomodulatory functions, including counteraction of the host restriction factor tetherin, downmodulation of CD4, and inhibition of NF-κB activity to facilitate HIV-1 infection. However, the relative contribution of individual Vpu functions to HIV-1 infection