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由来生物
rat
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
MOMA-2, monoclonal
交差性
mouse
メーカー／製品名
Chemicon®
テクニック
flow cytometry: suitable
immunohistochemistry: suitable
アイソタイプ
IgG2b
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
特異性
Recognizes an intracellular antigen of mouse macrophages and monocytes. It reacts strongly with macrophages in lymphoid organs such as tingible body macrophages and macrophages in T cell dependent areas and is extremely useful in immunohistochemistry. Reacts on all mouse strains tested.
アプリケーション
Research Category
炎症及び免疫
炎症及び免疫
Research Sub Category
炎症及び自己免疫疾患
炎症及び自己免疫疾患
Detect Macrophages/Monocytes using this Anti-Macrophages/Monocytes Antibody, clone MOMA-2 validated for use in FC, IH.
Flow Cytometry: membrane permeabilization is recommended for this application.
Immunohistology: FRESH frozen sections at 1:25. The epitope recognized by MAB1852 is formaline sensitive. Fixation in fresh, acetone at 4°C or colder is strongly recommended. Specimens must be completely air dried after acetone fixation. Formalin or PFA fixation is not recommended.
Because of the lower titer, enhanced detection systems such as our poly-HRP secondaries or biotin labelled secondary antibodies followed by SA-FITC are recommended.
Optimal working dilutions must be determined by end user.
Immunohistology: FRESH frozen sections at 1:25. The epitope recognized by MAB1852 is formaline sensitive. Fixation in fresh, acetone at 4°C or colder is strongly recommended. Specimens must be completely air dried after acetone fixation. Formalin or PFA fixation is not recommended.
Because of the lower titer, enhanced detection systems such as our poly-HRP secondaries or biotin labelled secondary antibodies followed by SA-FITC are recommended.
Optimal working dilutions must be determined by end user.
物理的形状
Protein A purified
Format: Purified
Protein A Purified mouse immunoglobulin in 10 mM sodium phosphate buffer (pH 7.4), 0.15 M NaCl, and 0.1% sodium azide as a preservative..
保管および安定性
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
アナリシスノート
Control
Macrophages, monocytes, lymphoid organs
Macrophages, monocytes, lymphoid organs
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MAB1852:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Pouneh Kermani et al.
The Journal of clinical investigation, 115(3), 653-663 (2005-03-15)
The neurotrophin brain-derived neurotrophic factor (BDNF) is required for the maintenance of cardiac vessel wall stability during embryonic development through direct angiogenic actions on endothelial cells expressing the tropomysin receptor kinase B (TrkB). However, the role of BDNF and a
Kai Meng et al.
Molecular medicine (Cambridge, Mass.), 21, 143-153 (2015-02-17)
Valsartan has a protective effect against hypertension and atherosclerosis in humans and experimental animal models. This study aimed to determine the effect of prolonged treatment with angiotensin II (Ang II) on atherosclerosis and the effect of valsartan on the activity
Muriel G Blin et al.
Journal of molecular and cellular cardiology, 130, 76-87 (2019-04-01)
The progression of atherosclerosis is based on the continued recruitment of leukocytes in the vessel wall. The previously described role of CD146 in leukocyte infiltration suggests an involvement for this adhesion molecule in the inflammatory response. In this study, we
Olivier Herbin et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(3), 605-612 (2012-01-10)
The immunoinflammatory response plays a critical role in the development and progression of atherosclerosis. Recent studies suggested an important role for regulatory T (Treg) cells in the inhibition of disease-related vascular inflammation. We hypothesized that induction of a specific Treg
Courtney Netherland-Van Dyke et al.
Journal of cardiology and therapeutics, 3(2), 53-63 (2015-09-29)
WIN55,212-2, a potent synthetic agonist of cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), reduces atherosclerosis in apolipoprotein E (ApoE) null mice. Although pharmacologic evidence suggests the anti-atherosclerotic effects of WIN55,212-2 are mediated via CB2, this remains
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