ABC429

Anti-VEGF-B Antibody

1 mg/mL, from rabbit

• 別名: Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBIアクセッション番号: NP_003368
• UniProtアクセッション番号: P49765
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... VEGFB(7423)

詳細

詳細

VEGF-B, also known as Vascular endothelial growth factor B, VEGF-related factor, VRF, and encoded by the gene VEGFB/VRF, is an endothelial cell growth factor that has multiple splice variants and plays roles in angiogenesis but also in cardiac muscle function, coronary vascular development, chemotaxis of endothelial cells and mast cells, apoptosis regulation, platelet activation, cell division, wound healing and the activation of various signaling pathways. VEGFB is a secreted protein that stays associated with cells because of its ability to bind to heparin. VEGFB is expressed in all cells except for liver cells with the highest levels found in muscle and pancreatic cells. VEGFB levels in plasma are also being studied as a potential biomarker for ventricle damage after heart attacks. High levels of plasma VEGFB show little remodeling whereas patients with lower levels had significant ventricle remodeling, thus VEGFB may have clinical utility in the identification of patients at high risk of remodeling and therefore ventricle damage.

免疫原

Epitope: Unknown

KLH-conjugated linear peptide corresponding to human VEGF-B.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Detect VEGF-B using this Anti-VEGF-B Antibody validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected VEGF-B in human skeletal muscle myocytes and vascular tissue and cardiac myocytes in human heart.

品質

Evaluated by Western Blotting in human skeletal muscle tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected VEGF-B in 10 µg of human skeletal muscle tissue lysate.

ターゲットの説明

~40/32/25 kDa observed. The ~40kDa band observed is likely due to homo and/or hetero-dimers, the ~32kDa band observed is likely due to glycosylation, and the ~25kDa band is un-modified VEGF186 (Olofsson, B., et al. (1998). Proc Natl Acad Sci USA. 95(20):11709-11714).

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable