ABC114

Anti-Thrombospondin-2 Antibody

from rabbit, purified by affinity chromatography

• 別名: Thrombospondin-2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 交差性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_003238
• UniProtアクセッション番号: P35442
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... THBS2(7058)

詳細

詳細

Thrombospondins (TSPs) are a family of homotrimeric multi-domain glycoproteins involved in modulation of cell adhesion, proliferation, and migration and have been implicated clinically in the development of atherosclerosis, angiogenesis, and oncogenesis. TSP2, a member of the thrombospondin family is a secreted protein, but is present only transiently in extracellular matrix and is rapidly internalized for degradation by fibroblasts after binding to the cell surface. It also interacts with matrix metalloproteinases (MMPs) and matrix serine proteases, such as plasminogen activator. TSP2 is reportedly controls the apoptosis-proliferation balance in endothelial cells. Although TSP2 is a potent inhibitor of angiogenesis, its N-terminal region exhibits pro-angiogenic activities mediated by beta 1 integrins. Loss of TSP2 expression is associated with local invasive behavior, tumor neovascularization, and metastasis. Decreased TSP2 expression has been correlated with malignant progression and angiogenesis in some cancers. TSP2 levels are also highly expressed in developing and healing tissues.

特異性

Other homologies: Mouse, Rat, and Bovine (93% sequence homology).

This antibody recognizes the Laminin G-like region of Thrombospondin-2.

免疫原

Epitope: Laminin G-like region

KLH-conjugated linear peptide corresponding to the Laminin G-like region of human Thrombospondin-2.

アプリケーション

Anti-Thrombospondin-2 Antibody is an antibody against Thrombospondin-2 for use in Western Blotting.

品質

Evaluated by Western Blot in concentrated conditioned media from MG-63 cells.

Western Blot Analysis: 0.25 µg/mL of this antibody detected Thrombospondin-2 in 10 µg of concentrated conditioned media from MG-63 cells.

ターゲットの説明

~180 kDa observed. The calculated molecular weight is 130 kDa, however Thrombospondin-2 has been shown to have bands at ~135 kDa and ~180 kDa in western blots (Streit, M., et al. (1999). PNAS. 96(26):14888-14893).

アナリシスノート

Control
Concentrated conditioned media from MG-63 cells

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable