869006-M

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

• 別名: Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
• CAS番号: 9002-71-5
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human pituitary glands
• 品質水準: 100
• 無菌性: non-sterile
• アッセイ: ≥95% (weight)
• 形状: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• テクニック: enzyme immunoassay: suitable
• 不純物: ≤0.1% hPRL (weight); ≤0.2% hGH, hFSH (weight); ≤0.3% hLH (weight)
• 溶解性: 0.05 M PBS: 1 mg/mL
• 輸送温度: dry ice
• 保管温度: −20°C
• 遺伝子情報: human ... TSHB(7252)

詳細

詳細

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

生物化学的／生理学的作用

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

警告

Toxicity: Standard Handling (A)

単位の定義

1mg/ml in 0.05M PBS

調製ノート

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable