8.22278

Acetic anhydride

for synthesis

• 別名: Acetic anhydride, Acetyl acetate, Acetyl oxide
• 化学式: (CH₃CO)₂O
• CAS番号: 108-24-7
• 分子量: 102.09
• MDL番号: MFCD00008705
• UNSPSCコード: 12352106
• EC Index Number: 203-564-8
• NACRES: NA.22

特性

• 蒸気圧: 4 hPa ( 20 °C)
• 品質水準: 200
• アッセイ: ≥98.0% (GC)
• 形状: liquid
• 自己発火温度: 330 °C
• 有効性: 630 mg/kg LD₅₀, oral (Rat); 4320 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 2.0-10.2 % (v/v)
• pH: 3 (20 °C, 10 g/L in H₂O)
• mp: -73 °C
• 転移温度: flash point 49 °C
• 密度: 1.08 g/cm³ at 20 °C
• 保管温度: 2-30°C
• InChI: 1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
• InChI Key: WFDIJRYMOXRFFG-UHFFFAOYSA-N

詳細

詳細

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

アプリケーション

Acetic anhydride is used:

• In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
• As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
• In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

アナリシスノート

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

安全性情報

• ピクトグラム: GHS02,GHS05,GHS06
• シグナルワード: Danger
• 危険有害性情報: H226 - H302 - H314 - H330
• 注意書き: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 120.2 °F - closed cup
• 引火点(℃): 49 °C - closed cup