688100

YC-1

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase.

• 別名: YC-1, 3-(5ʹ-Hydroxymethyl-2ʹ-furyl)-1-benzylindazole
• 実験式（ヒル表記法）: C₁₉H₁₆N₂O₂
• CAS番号: 170632-47-0
• 分子量: 304.34
• MDL番号: MFCD06407798
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: off-white to pale yellow
• 溶解性: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• InChI Key: OQQVFCKUDYMWGV-UHFFFAOYSA-N

詳細

詳細

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent.

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Activator of soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

その他情報

Yeo, E.J., et al. 2003. J. Natl Cancer Inst.95, 516.
Mulsch, A., et al. 1997. Br. J. Pharmacol. 120, 681.
Teng, C.M., et al. 1997. Eur. J. Pharmacol. 320, 161.
Wu, C.C., et al. 1997. Biochem. Biophys. Res. Commun. 231, 412.
Wu, C.C., et al. 1995. Br. J. Pharmacol. 116, 1973.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable