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詳細
Research area: Cancer
β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. It is a non-glycosylated protein, synthesized by all nucleated cells. Its secondary structure comprises of seven β-strands, arranged into two β-sheets connected by a single disulfide bridge.
β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. It is a non-glycosylated protein, synthesized by all nucleated cells. Its secondary structure comprises of seven β-strands, arranged into two β-sheets connected by a single disulfide bridge.
アプリケーション
β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.
生物化学的／生理学的作用
The interaction of β2 microglobulin (β2-M) with major histocompatibility complex (MHC) is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome. β2-M serves as a regulator of cell survival, proliferation, migration, invasion, apoptosis, angiogenesis, and metastasis in cancer cells. It is also recognized for promoting the growth and survival of stromal cells, such as mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, thereby supporting cancer bone metastasis.
調製ノート
Prepared by the method of Berggard and Bearn.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
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Jan Code
SAE0112-100UG-PW:
SAE0112-VAR:
SAE0112-BULK:
SAE0112-100UG:
SAE0112-1000UG-PW:
SAE0112-1000UG:
試験成績書（COA）
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The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator
Li L, et al.
Chinese Medical Journal (English Edition), 129(4), 448-455 (2016)
?2-Microglobulin-mediated Signaling as a Target for Cancer Therapy
Nomura T, et al.
Anticancer Agents in Medicinal Chemistry, 14(3), 343?352-343?352 (2014)
?2-Microglobulin: emerging as a promising cancer therapeutic target
Shi C, et al.
Drug Discovery Today, 14(1-2), 25-30 (2009)
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