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詳細
Contains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.
Protein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.
The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.
The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.
The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
生物化学的／生理学的作用
Product competes with ATP.
Secondary Target
PKC, Src family of protein tyrosine kinases, JAK2
PKC, Src family of protein tyrosine kinases, JAK2
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
調製ノート
Concentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.
その他情報
Hanke, J.H., et al. 1996. J. Biol. Chem.271 695.
Meydan, N., et al. 1996. Nature379, 645.
Levitzi, A., and Gazit, A. 1995. Science267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.
Meydan, N., et al. 1996. Nature379, 645.
Levitzi, A., and Gazit, A. 1995. Science267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral
保管分類コード
11 - Combustible Solids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
657021-1SET:
試験成績書（COA）
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