565749

β-Secretase Inhibitor II

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
• 実験式（ヒル表記法）: C₂₅H₃₉N₃O₅
• CAS番号: 263563-09-3
• 分子量: 461.59
• MDL番号: MFCD03453567
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: N([C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O)C(=O)OCc1ccccc1
• InChI: 1S/C25H39N3O5/c1-16(2)12-20(14-29)26-23(30)21(13-17(3)4)27-24(31)22(18(5)6)28-25(32)33-15-19-10-8-7-9-11-19/h7-11,14,16-18,20-22H,12-13,15H2,1-6H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
• InChI Key: YHUAFMGVVANYBT-FKBYEOEOSA-N

詳細

詳細

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
β-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Val-Leu-Leu-CHO

再構成

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

その他情報

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable