554994

RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells.

• 別名: RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane
• 実験式（ヒル表記法）: C₂₀H₃₄N₄O₄
• CAS番号: 83654-05-1
• 分子量: 394.51
• MDL番号: MFCD00210844
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white to off-white
• 溶解性: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
• InChI Key: RXSVYGIGWRDVQC-UHFFFAOYSA-N

詳細

詳細

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
DAG lipase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 nM against DAG lipase activity in canine platelets

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable