5.09721

1α,25-Dihydroxy Vitamin D3

InSolution, ≥99%

• 別名: InSolution Vitamin D3, 1α, 25-Dihydroxy-, 1,25-(OH)₂-D₃
• 実験式（ヒル表記法）: C₂₇H₄₄O₃
• 分子量: 416.64
• UNSPSCコード: 12352205
• NACRES: NA.21

特性

• 品質水準: 200
• アッセイ: ≥99% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 保管温度: −70°C

詳細

詳細

Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D₃. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca²⁺ and phosphate transport and mobilizes Ca²⁺ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.

アプリケーション

• Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D(3)-induced intestinal cell lines.: Ueno et al. developed an evaluation system for cell-permeable CYP3A4 inhibitory activity utilizing 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines. This system helps in screening for CYP3A4 inhibitors, which are critical in drug metabolism and interaction studies (Ueno et al., 2021).

生物化学的／生理学的作用

Primary Target
vitamin D receptor

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

物理的形状

A 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

その他情報

Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem.269, 3125.
Mathieu, C., et al. 1994. Diabetologica37, 552.
Thomasset, M. 1994. Pathol. Biol.42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - (refers to pure substance)
• 引火点(℃): 87 °C - (refers to pure substance)