5.08316

CTAP

• 別名: CTAP, µ opioid receptor antagonist, CTAP
• 実験式（ヒル表記法）: C₅₁H₆₉N₁₃O₁₁S₂
• CAS番号: 103429-32-9
• 分子量: 1104.30
• MDL番号: MFCD00671434
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• 形状: solid
• 有効性: 3.5 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: water: soluble
• 保管温度: −20°C
• InChI: 1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1
• InChI Key: OFMQLVRLOGHAJI-FGHAYEPSSA-N

詳細

詳細

A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC₅₀ = 3.5 nM). Used in studies of reward systems and additions.

生物化学的／生理学的作用

Primary Target
u Opioid receptpr

警告

Toxicity: Standard Handling (A)

シーケンス

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Perry, C., et al., 2013. Behav. Neurosci.127, 535.
Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.
Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.
Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.
Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable