475847

MIF Antagonist IV, RDR 03785

The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: MIF Antagonist IV, RDR 03785, Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol
• 実験式（ヒル表記法）: C₁₉H₁₈F₃NO₄
• CAS番号: 289657-30-3
• 分子量: 381.35
• UNSPSCコード: 12352200
• PubChem Substance ID: 2725942

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: cream
• 溶解性: DMSO: 50 mg/mL, clear, colorless
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: C1COCCN1C(C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3O)OCO4

詳細

詳細

A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (K_i and IC₅₀ = 0.57 and 2.4 µM, respectively) via direct non-covalent MIF interaction (K_D = 24.5 µM). RDR 03758 at 10 µM is shown to completely neutralize the overriding effect of 100 ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone (Cat. No. 265005) in RAW 264.7 marcophage cultures.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Ouertatani-Sakouhi, H., et al. 2010. J. Biol. Chem.285, 26581.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable