OK to freeze desiccated (hygroscopic) protect from light
色
white
溶解性
ethanol: 6 mg/mL DMSO: 60 mg/mL
輸送温度
ambient
保管温度
2-8°C
詳細
A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
調製ノート
Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
その他情報
Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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