155306-M

AMPA Agonist, CMPA

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

• 別名: AMPA Agonist, CMPA, N,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
• 実験式（ヒル表記法）: C₁₆H₂₈N₂O₄S₂
• 分子量: 376.53
• UNSPSCコード: 12352200
• PubChem Substance ID: 9969799

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder; solution
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: clear almost colorless; off-white
• 溶解性: DMSO: 100 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CC(C)S(=O)(=O)NCCC1=CC=C(C=C1)CCNS(=O)(=O)C(C)C

詳細

詳細

A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC₅₀ = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Timm, D., et al. 2011. Mol. Pharm.80, 267.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable