14-924-M

TYK2 Protein, active, 10 µg

Active, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end. For use in Kinase Assays.

• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 100; 300
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 40 kDa
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• NCBIアクセッション番号: NM_003331
• UniProtアクセッション番号: P29597

詳細

詳細

Product Source: N-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.

TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

アプリケーション

Research Category
細胞シグナル伝達

生物化学的／生理学的作用

Protein Target: TYK2

Target Sub-Family: TK

包装

Also available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.

品質

Routinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK

物理的形状

Purified using immobilized metal affinity chromatography followed by gel filtration.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable