14-842-M

Lck Protein, activated, 10 µg

activated, N-terminal 6His-tagged, recombinant, human Lck full length, for use in Kinase Assays.

• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 製品種目: Upstate^®
• 比活性: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 分子量: M_w 59 kDa
• 精製方法: (Ni²⁺/NTA-agarose)
• 交差性: human
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• アクセッション番号: (FUNCTION: SwissProt: P06239 # Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyp); NM_005356.3
• NCBIアクセッション番号: NM_005356.3
• UniProtアクセッション番号: P06239
• 関連疾患: obesity; metabolic disorders

詳細

詳細

N-terminal 6His-tagged, recombinant, human Lck full length

アプリケーション

Research Category
代謝

Research Sub Category
肥満

代謝障害

Auto-activated on column by incubating with Mg/ATP, excess ATP and MgAc removed by multiple column wash steps.

生物化学的／生理学的作用

Protein Target: Lck

Target Sub-Family: TK

包装

Also available in 10 μg size and in bulk

Also available in 250 µg size or bulk --call for pricing and availability and reference catalog number 14-842M when ordering the 250 µg size.

ターゲットの説明

Lck

関連事項

Replaces: 14-710

物理的形状

Ni²⁺/NTA-agarose

保管および安定性

1 year at -70°C from date of shipment

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(℃): Not applicable