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特異性
SHP1
免疫原
Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
細胞骨格シグナル伝達
細胞骨格シグナル伝達
This Anti-SHP-1/SHPTP-1 Antibody is validated for use in IP, WB for the detection of SHP-1/SHPTP-1.
品質
routinely evaluated by immunoblot in RIPA lysates from human A431 carcinoma cells
ターゲットの説明
65kDa
物理的形状
Protein A purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
Format: Purified
保管および安定性
1 year at 2-8°C
アナリシスノート
Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for mingels.
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for mingels.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
N Rivard et al.
The Journal of biological chemistry, 270(18), 11017-11024 (1995-05-05)
PTP1C and PTP1D are non-transmembrane protein-tyrosine phosphatases (PTPs), which contain two src homology-2 domains. These enzymes are believed to play a role in regulating downstream signaling from receptors with intrinsic tyrosine kinase activity. The present study describes the tyrosine phosphorylation
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
Ming-Can Yu, Liu-Li Su, Lin Zou, Ye Liu, Na Wu, Ling Kong, Zi-Heng Zhuang, Lei Sun et al.
Nature Immunology null
Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells.
Kazue Tsuji-Takayama, Takeshi Otani, Toshiya Inoue, Shuji Nakamura, Ryuichi Motoda et al.
Experimental Hematology null
Thierry Voisin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(6), 1993-2002 (2008-01-17)
Orexins acting at the G protein-coupled receptor (GPCR) OX1R have recently been shown to promote dramatic apoptosis in cancer cells. We report here that orexin-induced apoptosis is driven by an immunoreceptor tyrosine-based inhibitory motif (ITIM) (IIY(358)NFL) present in the OX1R.
Santosh Kumar et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 817-826 (2014-12-17)
Signaling by immunoreceptors is often initiated by phosphorylation of cytosolic tyrosines, which then recruit effector molecules. In the case of MHC class I-specific inhibitory receptors, phosphorylation of cytosolic tyrosine residues within ITIMs results in recruitment of a protein tyrosine phosphatase
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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