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詳細
Pro-Insulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). From every molecule of Pro-Insulin, one molecule of Insulin plus one molecule of C-peptide are produced. C-peptide is released into the blood stream in equal amounts to Insulin.
特異性
No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
The antibody C-PEP-01 reacts specifically with C-peptide, a part of the Pro-insulin molecule.
免疫原
Synthetic C-peptide of human pro-insulin conjugated to bovine serum albumin.
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
インスリン/エネルギーシグナル伝達
インスリン/エネルギーシグナル伝達
This Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 is validated for use in IH(P) for the detection of Pro-Insulin C-Peptide.
品質
Evaluated by Immunohistochemistry in normal human pancreas.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
ターゲットの説明
Approx. 12 kDa
関連事項
Replaces: CBL94
物理的形状
Sequential precipitation with caprylic acid and ammonium sulfate.
Format: Purified
Mouse monoclonal IgG1 in phosphate buffered saline, pH7.4, and 15 mM sodium azide.
保管および安定性
Store at 2-8°C and use within 1 year from date of receipt.
アナリシスノート
Control
Human normal pancreas tissue
Human normal pancreas tissue
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
05-1109:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Mahmoud M Gabr et al.
Scientific reports, 14(1), 17844-17844 (2024-08-02)
This study was to determine whether extracellular vesicles (EVs) derived from insulin-producing cells (IPCs) can modulate naïve mesenchymal stromal cells (MSCs) to become insulin-secreting. MSCs were isolated from human adipose tissue. The cells were then differentiated to generate IPCs by
Sapna Puri et al.
Nature communications, 9(1), 485-485 (2018-02-06)
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally
Mohammad Massumi et al.
PloS one, 11(10), e0164457-e0164457 (2016-10-19)
The ability to yield glucose-responsive pancreatic beta-cells from human pluripotent stem cells in vitro will facilitate the development of the cell replacement therapies for the treatment of Type 1 Diabetes. Here, through the sequential in vitro targeting of selected signaling
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.
Yamada, Mitsutoshi, et al.
Nature (2014)
Haiqing Hua et al.
The Journal of clinical investigation, 123(7), 3146-3153 (2013-06-20)
Diabetes is a disorder characterized by loss of β cell mass and/or β cell function, leading to deficiency of insulin relative to metabolic need. To determine whether stem cell-derived β cells recapitulate molecular-physiological phenotypes of a diabetic subject, we generated
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