700039P

24(S),25-epoxycholesterol

Avanti Research^™ - A Croda Brand

• 別名: (24S,25)-Epoxycholesterol, (3β,24S)-24,25-Epoxycholest-5-en-3-ol
• 実験式（ヒル表記法）: C₂₇H₄₄O₂
• CAS番号: 77058-74-3
• 分子量: 400.64
• MDL番号: MFCD03695562
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• フォーム: powder
• 包装: pkg of 1 × 1 mg (700039P-1mg); pkg of 1 × 5 mg (700039P-5mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: O1[C@H](C1(C)C)CC[C@H]([C@@H]2[C@@]3([C@H]([C@H]4[C@@H]([C@]5(CC[C@@H](CC5=CC4)O)C)CC3)CC2)C)C
• InChI: 1S/C27H44O2/c1-17(6-11-24-25(2,3)29-24)21-9-10-22-20-8-7-18-16-19(28)12-14-26(18,4)23(20)13-15-27(21,22)5/h7,17,19-24,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,24+,26+,27-/m1/s1
• InChI Key: OSENKJZWYQXHBN-XVYZBDJZSA-N

詳細

詳細

24(S),25-epoxycholesterol is an oxysterol, which is produced by fibroblasts, macrophages and brain cells.

24(S),25-epoxycholesterol is a cholesterol-derived oxysterol, which is produced by fibroblasts, macrophages, and the brain cells. 24(S),25-epoxycholesterol is synthesized de novo in the mevalonate pathway.

アプリケーション

24(S),25-epoxycholesterol has been used as an oxysterol/internalstandard to study the effects of AY9944-induced changes in neurospheres.

生物化学的／生理学的作用

Exogenous addition of 24(S),25-epoxycholesterol lowers 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase activity, represses sterol regulatory element-binding protein (SREBP) processing, and induces liver × receptor (LXR) -gene targets in vitro.

包装

5 mL Amber Glass Screw Cap Vial (700039P-1mg)

5 mL Amber Glass Screw Cap Vial (700039P-5mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids