920517

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid

• 別名: Rigid linker for PROTAC^® development
• 実験式（ヒル表記法）: C₁₅H₂₂N₄O₄
• CAS番号: 1700483-37-9
• 分子量: 322.36
• MDL番号: MFCD34602224
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• 反応適合性: reagent type: linker
• 品質水準: 100
• 官能基: Boc; carboxylic acid
• 保管温度: 2-8°C
• SMILES記法: CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C
• InChI: 1S/C15H22N4O4/c1-15(2,3)23-14(22)19-6-4-5-18(7-8-19)12-10-16-9-11(17-12)13(20)21/h9-10H,4-8H2,1-3H3,(H,20,21)
• InChI Key: JBZILBWYLNAFOB-UHFFFAOYSA-N

詳細

アプリケーション

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920525
920681

その他情報

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable