902683

BocNH-PEG5-acid

• 別名: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• 実験式（ヒル表記法）: C₁₇H₃₃NO₉
• CAS番号: 890152-41-7
• 分子量: 395.45
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• 形状: liquid
• 反応適合性: reaction type: Pegylations; reagent type: cross-linking reagent
• 官能基: Boc; amine; carboxylic acid
• 保管温度: −20°C
• SMILES記法: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable