765716

金ナノ粒子

20 nm diameter, methyl terminated, PEG 2000 coated, OD 50, dispersion in H₂O

• 別名: 金コロイド
• UNSPSCコード: 12162002
• NACRES: NA.23

特性

• 物質: PEG 2000
• フォーム: dispersion in H₂O; nanoparticles
• 包装: poly bottle of 1 mL
• OD: 50
• 直径: 20 nm
• pH: 6.0-8.0 (25 °C)
• 溶解性: water: miscible
• 密度: 1.00 g/cm³
• λmax: 520 nm
• 官能基: methoxy
• 保管温度: 2-8°C

詳細

詳細

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coatings are possible on smaller AuNPs. The methyl group, being hydrophobic, acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.[1][2][3]

アプリケーション

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Several other specific applications have been listed below:

• Since AuNPs adheres to cell membranes, they may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
• AuNPs may also be used in photothermal therapy and radiotherapy.
• AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.[1][2][3]

特徴および利点

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.[2]

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable