651753

2-クロロ-5-フルオロピリミジン

97%

• 実験式（ヒル表記法）: C₄H₂ClFN₂
• CAS番号: 62802-42-0
• 分子量: 132.52
• MDL番号: MFCD03788197
• UNSPSCコード: 12352100
• PubChem Substance ID: 24883860
• NACRES: NA.22

特性

• アッセイ: 97%
• 屈折率: n20/D 1.503 (lit.)
• 密度: 1.439 g/mL at 20 °C (lit.)
• 官能基: chloro; fluoro
• SMILES記法: Fc1cnc(Cl)nc1
• InChI: 1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
• InChI Key: AGYUQBNABXVWMS-UHFFFAOYSA-N

詳細

アプリケーション

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:

• 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K₂CO₃, via C-N bond forming reaction.[1]
• 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.[2]
• 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.[3]

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H314
• 注意書き: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• 危険有害性の分類: Acute Tox. 4 Oral - Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): 149.0 °F - closed cup
• 引火点(℃): 65 °C - closed cup
• 個人用保護具 (PPE): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter