532703

1-ブロモ-4-クロロ-2-フルオロベンゼン

98%

• 化学式: BrC₆H₃(Cl)F
• CAS番号: 1996-29-8
• 分子量: 209.44
• MDL番号: MFCD00079708
• UNSPSCコード: 12352100
• PubChem Substance ID: 24877906
• NACRES: NA.22

特性

• アッセイ: 98%
• 屈折率: n20/D 1.556 (lit.)
• bp: 91-92 °C/20 mmHg (lit.)
• 密度: 1.678 g/mL at 25 °C (lit.)
• SMILES記法: Fc1cc(Cl)ccc1Br
• InChI: 1S/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
• InChI Key: FPNVMCMDWZNTEU-UHFFFAOYSA-N

詳細

詳細

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}

アプリケーション

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative.[1] It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.[2]

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 198.0 °F - closed cup
• 引火点(℃): 92.2 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)