429856

2-アミノ-6-フルオロベンゾニトリル

99%

• 別名: 6-フルオロアントラニロニトリル
• 化学式: H₂NC₆H₃(F)CN
• CAS番号: 77326-36-4
• 分子量: 136.13
• MDL番号: MFCD00015477
• UNSPSCコード: 12352100
• PubChem Substance ID: 24866895
• NACRES: NA.22

特性

• アッセイ: 99%
• mp: 125-128 °C (lit.)
• 官能基: fluoro; nitrile
• 保管温度: 2-8°C
• SMILES記法: Nc1cccc(F)c1C#N
• InChI: 1S/C7H5FN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H2
• InChI Key: IQUNZGOZUJITBJ-UHFFFAOYSA-N

詳細

詳細

2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.

アプリケーション

2-Amino-6-fluorobenzonitrile, a medicinal chemistry intermediate, has been employed for the preparation of tacrine-related compounds. It may be used for the synthesis of antifolate and antibacterial quinazoline derivatives.
It may be used for the synthesis bis(4-oxoquinazolin-2-yl)pyridine and fluoro-containing quinazolin-4(1H)-ones. It may be employed for the synthesis of the following novel huprines:

• 12-amino-3-chloro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
• 9-allyl-12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride
• 12-amino-1-fluoro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
• 9-allyl-12-amino-1-fluoro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves