246611

リチウムジイソプロピルアミド

97%

• 別名: LDA
• 化学式: [(CH₃)₂CH]₂NLi
• CAS番号: 4111-54-0
• 分子量: 107.12
• Beilstein: 3655042
• EC Number: 223-893-0
• MDL番号: MFCD00064449
• UNSPSCコード: 12352001
• PubChem Substance ID: 24854817
• NACRES: NA.22

特性

• 蒸気密度: >1 (vs air)
• アッセイ: 97%
• 形状: solid
• 密度: 0.864 g/mL at 25 °C (lit.)
• SMILES記法: [Li]N(C(C)C)C(C)C
• InChI: 1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1
• InChI Key: ZCSHNCUQKCANBX-UHFFFAOYSA-N

詳細

詳細

Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran.

アプリケーション

Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds.
It can also be used as a base in:

• The direct alkylation and acylation of ketones.
• The aldol condensation reaction.
• α-Selenation reaction.
• The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds.
• The alkylation of acids, esters, amides, and nitriles.
• The initiation of anionic polymerization.

安全性情報

• ピクトグラム: GHS02,GHS05
• シグナルワード: Danger
• 危険有害性情報: H250,H314
• 注意書き: P231 + P232 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P370 + P378
• 危険有害性の分類: Eye Dam. 1 - Pyr. Sol. 1 - Skin Corr. 1B
• 補足的ハザード: EUH014
• 保管分類コード: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 2
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges