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Merck

ACHE

acetylcholinesterase

別名:
ACEE, ARACHE, N-ACHE, YT
Species:
UniProtKB ID:
遺伝子ID:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

製品番号
詳細
Species
Pyridine-2-aldoxime methochloride, ,
Species
human
(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;chloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Agonist

製品番号
詳細
Species
アセチルチオコリンクロリド, ≥99% (TLC), powder,
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
抗ACHE抗体 ヤギ宿主抗体, affinity isolated antibody, buffered aqueous solution,
交差性
cat, human, mouse, rabbit, rat
アプリケーション
ELISA
flow cytometry

immunofluorescence

western blot
Anti-Acetylcholinesterase (AChE) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
交差性
human
アプリケーション
immunofluorescence
western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
交差性
bovine, canine, chicken, guinea pig, human, monkey
アプリケーション
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
交差性
human
アプリケーション
immunofluorescence
Anti-ACHE, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
交差性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
アプリケーション
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
ドネペジル塩酸塩 塩酸塩 一水和物, ≥98% (HPLC),
Species
human
スコポレチン, ≥99%,
Species
human
臭化ピリドスチグミン, ,
Species
human
臭化ネオスチグミン, ≥98% (HPLC and titration), powder,
Species
human
ガランタミン 臭化水素酸塩 from Lycoris sp., ≥94% (HPLC),
Species
human

Kits

製品番号
詳細
Species
アセチルコリンエステラーゼ活性アッセイキット, sufficient for 100 colorimetric tests,
Species
mouse, human

Proteins

製品番号
詳細
Species
アセチルコリンエステラーゼ ヒト, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
Species
human
アセチルコリンエステラーゼ ヒト赤血球由来, buffered aqueous solution, ≥500 units/mg protein (BCA),
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human ACHE,
Species
human