N2001

臭化ネオスチグミン

≥98% (HPLC and titration), acetylcholinesterase inhibitor, powder

• 別名: 3-(N,N-ジメチルカルバモイロキシ)-N,N,N,-トリメチルアニリニウム ブロミド, プロスチグミン
• 実験式（ヒル表記法）: C₁₂H₁₉BrN₂O₂
• CAS番号: 114-80-7
• 分子量: 303.20
• NACRES: NA.77
• PubChem Substance ID: 24277854
• UNSPSC Code: 12352200
• EC Number: 204-054-8
• MDL number: MFCD00011795
• Assay: ≥98% (HPLC and titration)
• Form: powder

特性

• 製品名: 臭化ネオスチグミン, ≥98% (HPLC and titration), powder
• Quality Segment: 100
• assay: ≥98% (HPLC and titration)
• form: powder
• color: white
• mp: 175-177 °C (lit.)
• solubility: H₂O: 1 g/mL, ethanol: soluble
• SMILES string: [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
• InChI: 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• InChI key: LULNWZDBKTWDGK-UHFFFAOYSA-M
• Gene Information: human ... ACHE(43)

詳細

Application

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

• to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
• to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
• to study its effects on depolarization of bag cell neurons.[1]

Biochem/physiol Actions

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

アセチルコリンエステラ-ゼの可逆的阻害剤で、エセリンとほぼ同じですが、血液脳関門は通過しません。

アセチルコリンエステラ-ゼの可逆的阻害剤で、血液脳関門は通過しません。

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H317,H319,H334,H335
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• 保管分類: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges