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  • β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.

β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.

Biochemistry (2014-06-17)
Saurabh Gautam, Sandip Karmakar, Abhik Bose, Pramit K Chowdhury
ABSTRACT

Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and β-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the preformed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working toward the development of a suitable drug candidate for prevention and treatment of PD.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Curcumin, from Curcuma longa (Turmeric), powder
Sigma-Aldrich
β-ciclodestrina, ≥97%
Sigma-Aldrich
Thioflavin T, used as stain for amyloid
Sigma-Aldrich
Thioflavine S, practical grade
Sigma-Aldrich
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin)
Sigma-Aldrich
β-ciclodestrina, powder, BioReagent, suitable for cell culture, ≥97%
Sigma-Aldrich
β-ciclodestrina, produced by Wacker Chemie AG, Burghausen, Germany
USP
Curcumin, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
β-ciclodestrina, produced by Wacker Chemie AG, Burghausen, Germany, ≥95.0% (HPLC)
USP
Beta ciclodestrina, United States Pharmacopeia (USP) Reference Standard
Supelco
Curcumin, analytical standard
Sigma-Aldrich
β-ciclodestrina, Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, ≥98.0% (HPLC)
Supelco
β-ciclodestrina, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Curcumin, matrix substance for MALDI-MS, ≥99.5% (HPLC)
β-ciclodestrina, European Pharmacopoeia (EP) Reference Standard
Curcumin, primary reference standard