T9823

Tetracycline hydrochloride

Biotechnology Performance Certified, suitable for cell culture, ≥95%

• Formula empirica (notazione di Hill): C₂₂H₂₄N₂O₈ · HCl
• Numero CAS: 64-75-5
• Peso molecolare: 480.90
• Beilstein: 3844873
• Numero CE: 200-593-8
• Numero MDL: MFCD00078142
• Codice UNSPSC: 51101500
• ID PubChem: 24900607

Proprietà

• Grado: Biotechnology Performance Certified
• Saggio: ≥95%
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• Punto di fusione: 220-223 °C (lit.)
• Solubilità: H₂O: soluble 50 mg/mL
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1; XMEVHPAGJVLHIG-FMZCEJRJSA-N

Descrizione

Descrizione generale

Chemical structure: tetracycline

Applicazioni

Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne. It is used to study multidrug resistance as well as potential side effects such as acute pancreatitis. It has been used in target and resistance based mechanistic studies of novel antibiotics.

Azioni biochim/fisiol

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells. Mode of resistance is loss of cell wall permeability.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335,H361fd,H410
• Consigli di prudenza: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves