87128

Tetracycline

98.0-102.0% (HPLC)

• Sinonimo/i: Tetracycline HCL, Tetracycline Monohydrochloride
• Formula empirica (notazione di Hill): C₂₂H₂₄N₂O₈ · xH₂O
• Numero CAS: 60-54-8
• Peso molecolare: 444.43 (anhydrous basis)
• Beilstein: 2230417
• Numero CE: 200-481-9
• Numero MDL: MFCD00151232
• Codice UNSPSC: 51284017
• ID PubChem: 57653229
• NACRES: NA.85

Proprietà

• Origine biologica: synthetic
• Saggio: 98.0-102.0% (HPLC)
• Forma fisica: powder or crystals
• Colore: faint yellow to dark yellow
• Punto di fusione: 172-174 °C (dec.)
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1; OFVLGDICTFRJMM-WESIUVDSSA-N
• Informazioni sul gene: human ... CYP1A2(1544) , TERT(7015)

Descrizione

Descrizione generale

Chemical structure: tetracycline

Azioni biochim/fisiol

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Confezionamento

25g, 100g

Altre note

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H361fd,H411
• Consigli di prudenza: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves