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T6376

Sigma-Aldrich

Triamcinolone

Sinonimo/i:

9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Fluoxyprednisolone

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50 MG
70,40 €
250 MG
83,30 €
1 G
238,00 €

70,40 €

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Cambia visualizzazione
50 MG
70,40 €
250 MG
83,30 €
1 G
238,00 €

About This Item

Formula empirica (notazione di Hill):
C21H27FO6
Numero CAS:
124-94-7
Peso molecolare:
394.43
Numero CE:
204-718-7
Numero MDL:
MFCD00010477
Codice UNSPSC:
12352200
ID PubChem:
24278749
NACRES:
NA.77

70,40 €

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Punto di fusione

262-263 °C (lit.)

Solubilità

DMF: soluble 20 mg/mL
methanol: soluble 5 mg/mL
DMSO: soluble (Refer citation 16)

Ideatore

Abbott

Stringa SMILE

[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
GFNANZIMVAIWHM-OBYCQNJPSA-N

Informazioni sul gene

human ... NR3C1(2908) , PTGS2(5743)

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Applicazioni

Triamcinolone has been used as a corticosteroid standard for LC-MS-MS analysis[1]. Triamcinolone has also been used to study its effect on IgG and IgE levels in peripheral blood mononuclear cells (PBMCs)[2]

Azioni biochim/fisiol

Triamcinolone is a synthetic glucocorticoid agonist; induces gene expression and apoptosis; inhibits prostaglandin synthesis; impairs tumor necrosis factor (TNF)-α-induced degradation of κB-α; potentiates the differentiation-inducing effects of bone morphogenetic proteins (BMP-2, -4, -6).

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H351

Consigli di prudenza

P281

Classi di pericolo

Carc. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
WXBD8306V
MKCQ7236
MKCP2834
MKCN0750
MKCL3052

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Bioactive Molecules for Immunology Research

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